The Americas, which are sometimes collectively called America, are a landmass comprising the totality of North and South America. The Americas make up most of the land in Earth’s Western Hemisphere and comprise the New World. Humans first settled the Americas from Asia between 42,000 and 17,000 years ago. A second migration of Na-Dene speakers followed later from Asia. The subsequent migration of the Inuit into the neoarctic around 3500 BCE completed what is generally regarded as the settlement by the indigenous peoples of the Americas.